Dr. Comings' Publications #101-200
101. Burkholder, G.D. and Comings, D.E. Do the Giemsa-banding patterns of chromosomes change during embryonic
development? Exp. Cell Res. 75: 268-271, 1972.
102. Burkholder, G.D., Okada, T.A., and Cominos, D. Whole mount electron microscopy of metaphase I chromosomes
and microtubules from mouse oocytes. Exp. Cell Res. 75: 497-5ll, 1972.
103. Comings, D.E., Avelino, E., Okada, T.A., and Wyandt, H.E. The mechanism of C- and G-banding of
chromosomes. Exp. Cell Res. 77: 469-493, l973.
104. Comings, D.E., Avelino, E., and Becak, W. Heavy shoulder DNA in snakes. Cytogenet. Cell Genet. 12: 2-7, l973.
105. Comings, D.E. and Okada, T.A. DNA replication and the nuclear membrane. J. Mol. Biol. 75: 609-618, 1973.
106. Comings, D.E. Biochemical mechanisms of chromosome banding and color banding with acridine orange. Nobel
Symposium 23, Chromosome Identification Techniques and Applications in Biology and Medicine, T.
Caspersson and L. Zech (eds.), Academic Press, ,New York, pp. 293-299, l973.
107. Vaughan, S.T. and Comings, D..E. Cytoplasmic DNA binding proteins. Exp. Cell Res. 80: 265-274, 1973.
108. Comings, D.E. and Tack, L.O. Non-histone proteins. The effect of nuclear washes and comparison of metaphase
and interphase chromatin. Exp. Cell Res. 82: 175-191, 1973.
109. Comings, D.E. A general theory of carcinogenesis . Proc. Nat. Acad. Sci. USA 70: 3324-3328, 1973.
110. Comings, D.E. A model for the evolutionary origin or chromosome bands. Nature New Biol. 244: 576-577, 1973.
111. Comings, D.E., Avelino, E., Harris, D.C., Kovacs, B.W., and Tack, L.O. Proteins and chromosome banding
(Abstract). J. Cell Biol. 59: 51a, 1973.
112. Comings, D.E. and Okada, T.A. Some aspects of chromosome structure in eukaryotes. Cold Spring Harbor
Symposium on Quantitative Biology 38: 145-153, 1974.
113. Comings, D.E. The structure of human chromosomes. In The Nucleus, H. Busch (ed.), Academic Press, New York,
1: 537-563, 1974.
114. Comings, D.E. What is a chromosome break? In Chromosomes and Cancer, J. German (ed.), John Wiley and Sons,
New York, pp. 95-133, la74.
115. Comings, D.E. The role or heterochromatin. In Birth Defects, A. G. Motulsky and W. Lenz (eds.), Excerpta
Medica, Amsterdam, pp. 44-52, 1974.
116. Comings, D.E. and Amromin, G.D. Autosomal dominant insensitivity to pain with hyperplastic myelinopathy and
autosomal dominant indifference to pain. Neuro1ogy 24: 838-848, l974.
117. Comings, D.E. and Avelino, E. Mechanisms or chromosome banding. II. Evidence that histones are not involved.
Exp. Cell Res. 86: 202-206, 1974.
118. Okada, T.A. and Comings, D.E. Mechanisms of chromosome banding. III. Similarity between G-bands of mitotic
chromosomes and chromomeres of meiotic chromosomes. Chromosoma 48: 65-71, 1974.
119. Comings, D.E. Structure of mammalian chromosomes. In Physiologv and Genetics of Reproduction, E.M. Coutinho
and F. Fuchs (eds.), Plenum Press, New York, 4A: l9-27, 1974.
120. Comings, D.E., Kovacs, B.W., Avelino, E., and Harris, D.C. Mechanisms of Q-banding (Abstract). J. Cell Biol. 63:
68a, 1974.
121. Comings, D.E. and Okada, T.A. Is the nuclear membrane involved in DNA replication? In Mechanism and
Regulation or DNA Replication, A.R. Kolber and M. Kohiyama (eds.), Plenum Press, New York, pp.
321-326, l974.
122. Comings, D.E. Mechanisms of chromosome banding. IV. Optical properties of the Giemsa dyes. Chromosoma 50:
89-110, l975.
123. Comings, D.E., Kovacs, B.W., Avelino, E., and Harris, D.C. Mechanisms of chromosome banding. V. Quinacrine
banding. Chromosoma 50: 111-145, 1975.
124. Comings, D.E. and Okada, T.A. Mechanisms of chromosome banding. VI. Whole mount electron microscopv or
banded metaphasa chromosomes and a comparison with pachytene chromosomes. Exp. Cell Res. 93:
267-274, l975.
125. Comings, D.E. and Avelino, E. Mechanisms of chromosome banding. VII. Interaction of methylene blue with
DNA and chromatin. Chromosoma 50: 365-379, 1975.
126. Comings, D.E. Mechanisms of chromosome banding. VIII. Hoechst 33258-DNA interaction. Chromosoma
52:229-243, 1975 .
127. Conner, B.J., Harris, D.C., and Comings, D.E. Superiority of lyophilization over sodium dodecy1 sulfate (SDS)
in the preservation of chromatin for electrophoresis. Anal. Biochem. 67: 655-660, 1975.
128. Comings, D.E. Chromosome banding. J. Histochem. Cytochem. 23:461-462,1975.
129. Comings, D.E. Implications of somatic recombination and sister chromatid exchange in Bloom's
syndrome and cells treated with mitomycin C. Humangenetik 28: 191-l96, 1975.
130. Beutler, E., Kuhl, W., and Comings, D.E. Hexosaminidase isozyme in Type O Gm2 gangliosidosis
(Sandhoff-Jatzkewitz disease). Amer. J. Hum. Genet. 27: 628-638, 1975.
131. Comings, D.E. and Harris, D.C. Nuclear proteins. I. Electrophoretic comparison of mouse nucleoli,
heterochromatin, euchromatin and contractile proteins-. Exp. Cell Res. 96: 161-179, 1975.
132. Holmquist, G.P. and Comings, D.E. Sister chromatid exchange and chromosome organization based on a
bromodeoxyuridine Giemsa-C-banding technique (TC-banding). Chromosoma 52: 245-259, 1975.
133. Goetz, I., Roberts, E., and Comings, D.E. Fibroblasts in Huntington's disease. New Eng. J. Med. 293:
1225-1227, l975.
134. Comings, D.E. and Wyandt, H.E. Reverse banding of Japanese quail microchromosomes. Exp. Cell Res. 99:
83-185, l 976.
135. Comings, D.E. Chromosome organization. In Aspects of Genetics in Paediatrics, D. Barltrop (ed.),
Postgraduate Med. J. 52: 17-22, 1976.
136. Comings, D.E. and Drets, M.E. Mechanisms of chromosome banding. IX. Are variations in DNA base
composition adequate to account for quinacrine, Hoechst 33258 and daunomycin banding?
Chromosoma 56: l99-211, 1976.
137. Comings, D.E. and Okada, T.A. Fine structure of the heterochromatin of the kangaroo rat, Dipidomvs ordii,
and examination of the possible role of actin and myosin in heterochromatin condensation.
J. Cell Sci. 21: 465-477, l976.
138. Comings, D. E. and Harris, D.C. Nuclear proteins. II. Similarity of nuclear sap and chromatin non-histone proteins
and essential absence of contractile proteins from mouse liver nuclei. J. Cell Biol. 70: 440-452, l976.
139. Comings, D.E. and Okada, T.A. Nuclear prateins. III. The fibrillar Nature of the nuclear matrix.
Exp. Cell Res. 103: 341-360, 1976.
140. Holmquist, G.P. and Comings, D.E. Histones and G-banding of chromosomes. Science 193: 599-602, 1976.
141. Roberts, E., Goetz, I. and Comings, D.E. A note on experimental approaches to Huntington's disease.
In The Basal Ganglia, M.D. Yahr (ed.), Raven Press, New York, pp. 331-336, 1976.
142. Comings, D.E. and Okada, T.A. The fibrillar Nature of the nuclear matrix (Abstract). Presented at the First
International Congress of Cell Biology, Boston, Massachusetts, September 1976, and the
Fifth International Congress of Human Genetics, Mexico City, Mexico, October 1976.
143. Conner, B.J. and Comings, D.E. Histone-binding proteins (Abstract). Presented at the First International
Congress of Cell Biology, Boston, Massachusetts, September 1976.
144. Comings, D.E., Harris, O.C., Okada, T.A., and Holmquist, G. Nuclear proteins. IV. Deficiency of non-histone
proteins in condensed chromatin of Drosophila virilis and mouse. Exp. Cell Res. 105: 349-365, 1977.
145. Lin, M.S., Comings, D.E. and Alfi, O.S. Optical studies of the interaction of 4'-6-diamidino-2-phenylindole with
DNA and metaphase chromosomes . Chromosoma 60: 15-25, 1977.
146. Comings, D.E. Undiscovered Chromosomal proteins. In Chromosomes: From Simple to Complex.
Proceedings of the Thirty-fifth Annual Biology Colloquium, Oregon State University Press, pp. 37-42, 1977.
147. Comings, D.E. Chromosome banding and Chromosomal proteins. In ICN-UCLA Symposium on Molecular
Human Cytogenetics, Keystone, Colorado, March 1977.
148. Comings, D.E. When should you consider amniocentesis? Resident and Staff Physician 23: 52-61, 1977.
149. Ruoslahti, E., Engvall, E., Jalanko, H., and Comings, D.E. Antigenic differences in nuclear proteins of normal
1iver and hepatoma. J. Exp. Med. 146: 1054-1067, 1977.
150. Comings, D.E. Mammalian chromosome structure. In Chromosomes Today, A. de-la Chapell and M. Sousa (eds.),
Elsevier/North Holland Biomedical Press, Amsterdam, 6: 19-26, 1977.
151. Lehmann, H., Huntsman, R.S., Casey, R., Lang, A., Lorkin, P.A., and Comings, D.E. Erythrocyte disorders -
anemias related to abnormal globin. In Hematology, second edition, W.J. Williams, E. Beutler, A.J. Erslev, and
R.W. Rundles (eds.), McGraw-Hill, New York, chapter 55, pp. 495-524, 1977.
152. Stack, S.M. and Comings, D.E. Characterization of the DNA and chromosomes of Allium cepa. J. Cell Biol. 75:
136a, 1977.
153. Lesser, B.H. and Comings, D.E. Specific interaction between mouse liver nonhistone proteins and mouse
DNA. J. Cell Biol. 75: 123a, 1977.
154. Sparkes, R.S., Comings, D.E., and Fox, C.F. (eds.) Molecular Human Cytogenetics, ICN-UCLA Symposia,
vol. VII, 479, 1977.
155. Conner, B.J. and Comings, D.E. Studies of histone-binding proteins by affinity chromatography. Biochem.
Biophys. Acta 532: 122 136, 1978.
156. Comings, D.E. Methods and mechanisms of chromosome banding. In Methods in Cell Biology Chromatin and
Chromosomal Protein Research, Academic Press, New York, 17: 115-132, 1978.
157. Comings, D.E. Compartmentalization of nuclear and chromatin proteins. In The Cell Nucleus, H. Busch (ed.),
Academic Press, New York, 4: 345-371, 1978.
158. Lesser, B.H. and Comings, D.E. Specific interaction between mouse liver nonhistone Chromosomal proteins and
mouse DNA demonstrated by a sequential DNA-protein filter binding assay. Biochim. Biophys. Acta 521:
117-125, 1 978.
159. Comings, D.E. and Wallach, A.S. DNA binding properties of nuclear matrix proteins. J. Cell Sci. 34: 233-246,
1978.
160. Drets, M.E., Folle, G.A. and Comings, D.E. Mechanisms of chromosome banding. X. Chromosome and nuclear
changes induced by photo-oxidation and their relation to R-banding by anti-C antibodies. Chromosoma 69:
101-112, 1978.
161. Comings, D. E. Mechanisms of chromosome banding and their implication for chromosome structure. Ann. Rev.
Genet. 12: 25-46, 1978.
162. Comings, D.E., Limon, J., Ledochowski, A., and Tsou, K.C. Mechanisms or chromosome banding. XI. The ability
of various acridine derivatives to cause Q-banding. Exp. Cell Res. 117: 451-455, 1978.
163. Comings, D.E., Hd, Duarte and Hd ,S. Mutant alleles in Huntington's chorea and schizophrenia? (Abstract). Clin.
Res., 1978.
164. Comings, D.E., Pcl-Duarte: A common polymorphism or a human brain specific protein with increased frequency
in multiple sclerosis. (Abstract) American Society for Human Genetics Meetings, Vancouver, British Columbia,
October 1978.
165. Stack, S. M. and Comings, D.E. The chromosome and DNA of Allium cepa. (Abstract) J. Cell Biol. 79: l06a,
1978. Presented at the Eighteenth Annual Meeting of the American Society for Cell Biology.
166. Stack, S.M. and Comings, D.E. The chromosomes and DNA of Allium cepa. Chromosoma 70: 161-181, 1979.
167. Comings, D.E. Pcl-Duarte: A common polymorphism of a human brain protein, its relationship to depressive
disease and multiple sclerosis. Nature 277: 29-32, 1979.
168. Comings, D.E. and Cohen, L.W. Two-dimensional gel electrophoresis of 125 I-labeled surface proteins of human
fibroblasts. Biochim. Biophys. Acta 598: 61-67, 1974.
169. Okada, T.A. and Comings, D.E. Higher order structure of chromosomes. Chromosoma 72: 1-14, 1979.
170. Goetz, I., Roberts, E., Warren, J. and Comings, D.E. Growth of Huntington's disease fibroblasts during their in vitro
lifespan. Advances in Neurology 23: 351-359, I979.
171. Comings, D.E. A search for the mutant protein in Huntington disease and schizophrenia. In Second International
Symposium on Huntington's Disease. T. Chase, N. Wexler, and A. Barbeau (eds.), Advances in Neurology
23: 335-349, 1979 .
172. Comings, D.E. and Peters, K.E. Triple-spot proteins in two-dimensional gel electrophoresis. Amer. J. Hum. Genet.
31: 311-314, 1979.
173. Rouslahti, E. Pekkala, A., Comings, D.E., and Seppala, M. Determination of subfractions of amniotic fluid alpha-
fetoprotein in diagnosing spina bifida and congenital nephorsis. Brit. Med. J. 2: 768-769, 1979.
174. Comings, D.E. Powerful new tools in human genetics. (Editorial) Amer. J. Hum. Genet. 31: 647-648, l979.
175. Peters, K.E. and Comings, D.E. Two-dimensional gel electrophoresis of nuclear sap, nuclear matrix, nuclear
membrane, nuclear matrix and HnPNP proteins. J. Cell Biol. 83: 158a, 1979.
176. Conner, D.J. and Comings, D.E. Isolation and characterization of a histone-binding protein (HMG1) from mouse
liver by hydrophobic affinity chromatography. J. Cell Biol. 83: 156a, 1979.
177. Comings, D.E. and Okada, T.A. Chromosome scaffolding structure - Real or artifact? J. Cell Biol. 83: 150a, 1979.
178. Comings, D.E. Arrangement of chromatin in the nucleus. (Review Article) Hum. Genet. 53: 131-143, 1980.
179. Comings, D.E., LeFever, L.C., Ben-Yoseph, Y., and Nadler, H.L. Normal two-dimensional gel electrophoresis of
α-2-macroglobulin in cystic fibrosis. Amer. J. Hum. Genet. 32: 273-275, l980..
180. Peters, K.E. and Cominas, D.E. Two-dimensional gel electrophorests of rat liver nuclear washes, nuclear matrix,
and HnRNA proteins. J. Cell Biol. 86: 135-15-, 1980.
181. Okada, T.A. and Comings, D.E. A search for protein cores: Evidence the scaffold is an artifact. Amer. J. Hum.
Genet. 32: 814-832, 1980.
182. Comings, D.E., Peters, K.E., Okada, T.A. and Muhleman, D. Non-histone proteins of chromosomes and the
nucleus. European J. Cell Biol. 22:113, l980. Presented at the Second International Congress of Cell
Biology, West Berlin, August, l980.
183. Comings, D.E. Pcl-Duarte - A polvmorphism assoclated with depression. In. Genetic Strategies in Psvchobiologv
and Psychiatry, E.S. Gershorn and S. Matthysee (eds.), Boxwood Press, pp. 59-64, 1981.
184. Comings, D.E. Application of two-dimensional gel electrophoresis, recombinant DNA and tissue culture techniques
to the major psychoses. In Genetic Strategies In Psychobiology and Psychiatry, E.S. Gershorn and S.
Matthysee (eds.), Boxwood Press, pp. 389-393, 1981.
185. Comings, D.E., Pekkala, A., Schuh, J.R., Kuo, P.C., Chan, S.I. Huntington disease and Tourette syndrome. I.
Electron spin resonance or red blood cell ghosts. Amer. J. Human Genet. 33: 166-174, 1981.
186. Comings, D.E., Geotz, I.E., Holden, J. and Holtz, J. Huntington disease and Tourette syndrome. II. Uptake of
glutamic acid and other amino acids by fibroblasts. Amer. J. Hum. Genet.. 33: 175-186, l981
187. Comings, D.E. The ups and downs of Huntington disease research (Editorial) Amer. J. Hum. Genet. 33: 314-315,
l981.
188. Conner, B.J. and Comings, D.E. Isolation of a non-histone Chromosomal high mobility group protein from mouse
liver nuclei by hydrophobic chromatography. J. Biol. Chem. 256: 3283-329l, l981.
189. Comings, D.E. and Peters, K.E. Two-dimensional gel electrophoresis of nuclear particles. In The Cell Nucleus, H.
Busch (ed ), Academic Press, vol. IX, 89-118, 1981.
190. Ruoslahti, E., Jalanko, H., Comings, D.E., Neville, A.M. and Raghaven, D. Fibronectin from human germ cell
tumors resembles amniotic fluid fibronectin. Int. J. Cancer 27: 763, 1981.
l91. Comings, D.E. and Gursey, B.T. Behavior-problems in Tourette syndrome. Are they secondary to the disease of
stereotyped behaviors? (Abstract) First International Gilles de la Tourette Syndrome Symposium, New York,
May, 1981.
192. Comings, D.E. Additional Charge isomer of glial fibrillary acidic protein in autosomal dominant familial fetal
Parkinsonism with mental depression. Amer. J. Human Genet. 33: 37A, 1981.
193. Comings, D.E. Two-dimensional gel electrophoresis of human brain proteins I. Technique and nomenclature. Clin.
Chem. 28: 782-789, 1982.
194. Comings, D.E., Carraway, N. and Pekkala-Flagan, A. Two-dimensional gel electrophoresis of human brain
proteins. II. Specific proteins and brain sub-fractions. Clin. Chem. 28: 79O-797, 1982.
195. Comings, D.E. Two-dimensional gel electrophoresis or human brain proteins. III. Genetic and non-genetic
variations in 145 brains. Clin. Chem. 28: 798-804, 1982.
196. Comings, D.E. Two-dimensional gel electrophoresis of human brain proteins. IV. Disorders or glial proliferation.
Clin. Chem. 28: 805-812, 1982.
197. Comings, D.E. and Pekkala-Flagan, A. Two-dimensional gel electrophoresis of human brain proteins. V. Non-
equilibrium gel electrophoresis, with detection of a myelin basic protein mutation - MBL-Duarte. Clin. Chem.
28: 813-818, 1982.
198. Comings, D.E., Gursey, B.T., Avelino, E., Hopp, U. and Hanin, I. Red blood cell choline in Tourette syndrome.
In Gilles de la Tourette Syndrome, Proceedings of the First International Symposium, Raven Press,
Advances in Neurology 35: 255-258, 1982.
199. Comings, D.E., Gursey, B.T., Hecht, T. and Blum, K. HLA typing in Tourette syndrome
In Gilles de la Tourette Syndrome, Proceedings or the First International Symposium, Raven Press,
Advances in Neurology 35: 251-253, 1982.
200. Comings, D.E. and Gursey, B.G. Familial exhibitionism in Tourette syndrome successfully treated with
Haloperidol. Amer. J. Psychiatry 139: 913-915, 1982.